Grupoby Fillna
In [2400]: df
Out[2400]:
A B C D
0 1 1 1 1.0
1 1 1 1 NaN
2 1 1 1 3.0
3 3 3 3 5.0
In [2401]: df['D'].fillna(df.groupby(['A','B','C'])['D'].transform('mean'))
Out[2401]:
0 1.0
1 2.0
2 3.0
3 5.0
Name: D, dtype: float64
In [2402]: df['D'] = df['D'].fillna(df.groupby(['A','B','C'])['D'].transform('mean'))
In [2403]: df
Out[2403]:
A B C D
0 1 1 1 1.0
1 1 1 1 2.0
2 1 1 1 3.0
3 3 3 3 5.0
Gifted Gecko